3115501-20-4
Chemical Structure
PROTAC NLRP3 degrader-1
- CAS No.: 3115501-20-4
- Formula:C52H67N9O8S3
- Molecular Weight:1042.34
InChIKey: MTGYUSXJHPQTCP-BTPZHPEPSA-N
SMILES: O=S(NC(NC1=C2C(CCC2)=CC3=C1CCC3)=O)(C4=CC(C(O)(C5=CN(N=N5)CCCCCCCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(N[C@H](C7=CC=C(C8=C(N=CS8)C)C=C7)C)=O)=O)=O)C)=CS4)=O
Biological Activity: PROTAC NLRP3 degrader-1 is a PROTAC degrader targeting NLRP3. PROTAC NLRP3 degrader-1 recruits VHL E3 ubiquitin ligase to form a ternary complex with NLRP3, inducing VHL-dependent ubiquitination and proteasomal degradation of the inflammasome sensor NLRP3. PROTAC NLRP3 degrader-1 reduces IL-1β release. PROTAC NLRP3 degrader-1 can be used for research on NLRP3-related inflammation, metabolic inflammation, and cancer[1].
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PROTAC NLRP3 degrader-1 | PROTAC NLRP3 degrader-1 is a PROTAC degrader targeting NLRP3. PROTAC NLRP3 degrader-1 recruits VHL E3 ubiquitin ligase to form a ternary complex with NLRP3, inducing VHL-dependent ubiquitination and proteasomal degradation of the inflammasome sensor NLRP3. PROTAC NLRP3 degrader-1 reduces IL-1β release. PROTAC NLRP3 degrader-1 can be used for research on NLRP3-related inflammation, metabolic inflammation, and cancer. | |||||||||||||||||||||
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