3118854-61-5
Chemical Structure
HOXA1-IN-1
- CAS No.: 3118854-61-5
- Formula:C23H31NO2
- Molecular Weight:353.50
InChIKey: UFYLCTWDNUMDPB-UHFFFAOYSA-N
SMILES: CC1=CC(C)=CC=C1NC(C2=C(O)C=CC(C(C)(C)CC(C)(C)C)=C2)=O
Biological Activity: HOXA1-IN-1 is a HOXA1 inhibitor. HOXA1-IN-1 downregulates HOXA1 protein levels, suppresses its transcriptional activity, and alters the expression of its downstream target genes. HOXA1-IN-1 induces DNA damage and apoptosis in cancer cells. HOXA1-IN-1 exhibits antitumor efficacy in xenograft models of colorectal cancer and triple-negative breast cancer. HOXA1-IN-1 shows synergistic activity in combination with Cisplatin (HY-17394). HOXA1-IN-1 can be used for the research of colorectal cancer and triple-negative breast cancer[1].
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HOXA1-IN-1 | HOXA1-IN-1 is a HOXA1 inhibitor. HOXA1-IN-1 downregulates HOXA1 protein levels, suppresses its transcriptional activity, and alters the expression of its downstream target genes. HOXA1-IN-1 induces DNA damage and apoptosis in cancer cells. HOXA1-IN-1 exhibits antitumor efficacy in xenograft models of colorectal cancer and triple-negative breast cancer. HOXA1-IN-1 shows synergistic activity in combination with Cisplatin (HY-17394). HOXA1-IN-1 can be used for the research of colorectal cancer and triple-negative breast cancer. | |||||||||||||||||||||
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