3120750-94-6
Chemical Structure
KIF18A-IN-20
- CAS No.: 3120750-94-6
- Formula:C28H33F2N7O3S
- Molecular Weight:585.67
InChIKey: ORCADPIVZYTRHH-KDURUIRLSA-N
SMILES: O=S(NC1=CC=C(C(NC2=CN3C(C(N4CCC(F)(F)CC4)=N2)=NC=C3)=O)C(N5C[C@H]6C7(CC7)[C@H](CC6)C5)=C1)(C)=O
Biological Activity: KIF18A-IN-20 is an orally active KIF18A inhibitor with an IC50 of 52 nM. KIF18A-IN-20 targets the plus-end-directed mitotic kinesin KIF18A, regulating chromosome alignment and spindle dynamics, and inhibits the proliferation of chromosomally unstable OVCAR-3 ovarian cancer cells with EC50 = 3.4 nM. KIF18A-IN-20 achieves tumor regression in xenograft models without causing body weight loss. KIF18A-IN-20 can be used for research related to ovarian cancer[1].
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KIF18A-IN-20 | KIF18A-IN-20 is an orally active KIF18A inhibitor with an IC50 of 52 nM. KIF18A-IN-20 targets the plus-end-directed mitotic kinesin KIF18A, regulating chromosome alignment and spindle dynamics, and inhibits the proliferation of chromosomally unstable OVCAR-3 ovarian cancer cells with EC50 = 3.4 nM. KIF18A-IN-20 achieves tumor regression in xenograft models without causing body weight loss. KIF18A-IN-20 can be used for research related to ovarian cancer. | |||||||||||||||||||||
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