312749-73-8
312749-73-8
Chemical Structure
CLP-3094
- CAS No.: 312749-73-8
- Formula:C15H13ClN2OS
- Molecular Weight:304.79
IUPAC Name: 2-((2-(4-chlorophenoxy)ethyl)thio)-1H-benzo[d]imidazole
InChIKey: KZEWVENYWPSSOZ-UHFFFAOYSA-N
SMILES: ClC1=CC=C(OCCSC2=NC3=CC=CC=C3N2)C=C1
Biological Activity: CLP-3094 is a potent BF3 (binding function 3)-directed inhibitor of the androgen receptor (AR). CLP-3094 inhibits AR transcriptional activity (IC50=4 μM)[1]. CLP-3094 is a selective, potent GPR142 antagonist[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CLP-3094 | 99.92% | CLP-3094 is a potent BF3 (binding function 3)-directed inhibitor of the androgen receptor (AR). CLP-3094 inhibits AR transcriptional activity (IC50=4 μM). CLP-3094 is a selective, potent GPR142 antagonist. | ||||||||||||||||||||
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References
- [1]. Munuganti RS, et al. Targeting the binding function 3 (BF3) site of the androgen receptor through virtual screening. 2. development of 2-((2-phenoxyethyl) thio)-1H-benzimidazole derivatives. J Med Chem. 2013;56(3):1136-1148. [Content Brief]
- [2]. Murakoshi M, et al. Discovery and pharmacological effects of a novel GPR142 antagonist. J Recept Signal Transduct Res. 2017;37(3):290-296. [Content Brief]
