3132184-09-6
Chemical Structure
GL-637
- CAS No.: 3132184-09-6
- Formula:C37H45FN6O5S
- Molecular Weight:704.85
InChIKey: NHHCCHFVTFBHRK-OEWYDPHRSA-N
SMILES: O=C(OC)/C=C/C(NNC(CCC1=CC=C(N2CCN(C)CC2)C=C1C(N[C@@H](C3=CC=CC(C4=CC=C(CN5C[C@@H](F)CC5)S4)=C3)C)=O)=O)=O
Biological Activity: GL-637 is a covalent and selective inhibitor of SARS-CoV-1/2 papain-like protease (PLpro), with IC50 values of 42.4 nM and 50.5 nM against the two viruses, respectively. GL-637 covalently modifies the catalytic Cys111 of PLpro, binds to Glu167 and occupies the BL2 groove, thereby inhibiting the deubiquitinase and deISGylase activities of PLpro. GL-637 can be used in the research of coronaviruses[1].
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GL-637 | GL-637 is a covalent and selective inhibitor of SARS-CoV-1/2 papain-like protease (PLpro), with IC50 values of 42.4 nM and 50.5 nM against the two viruses, respectively. GL-637 covalently modifies the catalytic Cys111 of PLpro, binds to Glu167 and occupies the BL2 groove, thereby inhibiting the deubiquitinase and deISGylase activities of PLpro. GL-637 can be used in the research of coronaviruses. | |||||||||||||||||||||
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Keywords
