314297-32-0
314297-32-0
Chemical Structure
MK181
- CAS No.: 314297-32-0
- Formula:C16H13BrClNO4
- Molecular Weight:398.64
IUPAC Name: 2-(2-((4-bromobenzyl)carbamoyl)-5-chlorophenoxy)acetic acid
InChIKey: PAOIFRPAIJVWIK-UHFFFAOYSA-N
SMILES: O=C(COC1=CC(Cl)=CC=C1C(NCC2=CC=C(C=C2)Br)=O)O
Biological Activity: MK181 is an aldose reductase (AR) inhibitor with IC50s of 0.71 μM and 4.5 μM for aldose reductase and AKR1B10, respectively. MK181 can bind into the external loop A subpocket of AKR1B10[1].
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MK181 | MK181 is an aldose reductase (AR) inhibitor with IC50s of 0.71 μM and 4.5 μM for aldose reductase and AKR1B10, respectively. MK181 can bind into the external loop A subpocket of AKR1B10. | |||||||||||||||||||||
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References
Keywords
