330970-70-2
Chemical Structure
Alloc-Val-Ala-OH
Synonym(s): ((Allyloxy)carbonyl)-L-valyl-L-alanine
- CAS No.: 330970-70-2
- Formula:C12H20N2O5
- Molecular Weight:272.30
IUPAC Name: ((allyloxy)carbonyl)-L-valyl-L-alanine
InChIKey: LOIWGNGKOQWZSA-IUCAKERBSA-N
SMILES: OC([C@H](C)NC([C@H](C(C)C)NC(OCC=C)=O)=O)=O
Biological Activity: Alloc-Val-Ala-OH (((Allyloxy)carbonyl)-L-valyl-L-alanine) is a building block in the synthesis of Tesirine, a clinical antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Alloc-Val-Ala-OH | Alloc-Val-Ala-OH (((Allyloxy)carbonyl)-L-valyl-L-alanine) is a building block in the synthesis of Tesirine, a clinical antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer. | |||||||||||||||||||||
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Acetyltrialanine | 99.16% | Acetyltrialanine is a peptide containing three amino acid residues in which the N-terminal amino acid is acetylated and used as a substrate for Nα-acetyl alanine aminopeptidase in order to study the activity and properties of the enzyme. Acetyltrialanine can be used in the study of protein degradation and N-terminal regulation. | ||||||||||||||||||||
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Z-Val-Ala-OH | 99.78% | Z-Val-Ala-OH is a dipeptide derivative of valine and alanine. Z-Val-Ala-OH undergoes cleavage by cathepsin B and other lysosomal proteases to enable payload release following lysosomal internalization. Z-Val-Ala-OH can be used for the research of antibody-drug conjugate (ADC) development. | ||||||||||||||||||||
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D-{Ala-Ala-Ala} | D-{Ala-Ala-Ala} is a tripeptide. D-{Ala-Ala-Ala} binds to ristocetin to detect bacteria at low concentrations. | |||||||||||||||||||||
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Tri-valine | Tri-valine (NSC 35938) is a polypeptide that can be separated from Creatine kinase (HY-P2799), β-enolase, Triosephosphate isomerase (HY-P2931) and glyceraldehyde 3-phosphate dehydrogenase. | |||||||||||||||||||||
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Ac-VAD-CHO | Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor. Ac-VAD-CHO inhibits dissipation of MMP and cytochrome c release in hypoxia-exposed cells. | |||||||||||||||||||||
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Ala-Ala-Ala | Ala-Ala-Ala is an alanine derivative. | |||||||||||||||||||||
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(tert-Butoxycarbonyl)-L-valyl-L-alanine | 98.0% | (tert-Butoxycarbonyl)-L-valyl-L-alanine is an alanine derivative. | ||||||||||||||||||||
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(tert-Butoxycarbonyl)-L-valylglycine | 97.0% | (tert-Butoxycarbonyl)-L-valylglycine is a Glycine (HY-Y0966) derivative. | ||||||||||||||||||||
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Boc-Ala-Ala-OH | 99.04% | Boc-Ala-Ala-OH (NSC 334362) is a Boc-protected dipeptide and molecular building block. Boc-Ala-Ala-OH binds to metallopeptide cage 12. Boc-Ala-Ala-OH serves as a precursor for Boc-Ala-Ala-Asp-SBzl and Boc-Ala-Ala-Asp-CH2Cl. | ||||||||||||||||||||
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(tert-Butoxycarbonyl)-L-valyl-L-valine | 97.0% | (tert-Butoxycarbonyl)-L-valyl-L-valine is a valine derivative. | ||||||||||||||||||||
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