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Cat. No.: HY-P2931

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Triosephosphate isomerase

(Synonyms: TPI)

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Triosephosphate isomerase (TPI) is a biocatalyst that interconverts dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. Triosephosphate isomerase utilises Glu167 as catalytic base, mediates proton shuttling, and stabilises a cis-enediolate intermediate via loop-6 and loop-7 closure to shield its catalytic site. Triosephosphate isomerase can be used for the research of triosephosphate isomerase deficiency.

For research use only. We do not sell to patients.

CAS No.: 9023-78-3

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Triosephosphate isomerase Chemical Structure

CAS No.: 9023-78-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Clinical Trial
- EC Number
- Specific Activity
- Unit Definition
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Triosephosphate isomerase efficiently catalyzes the stereospecific isomerization of DHAP to D-GAP, with a k_cat of ~500 s^-1; the k_cat for the reverse reaction catalyzed by this enzyme is 5,000 s^-1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

EC Number

5.3.1.1

Specific Activity

≥10000 U/mg protein

Unit Definition

One unit is defined as the amount of enzyme that will convert 1.0 μmole D-glyceraldehyde 3- phosphate to dihydroxyacetone phosphate per min at pH 7.6 at 25°C.

Chemical Information

CAS No. 9023-78-3
Appearance Solid
Color White to off-white
SMILES

[Triosephosphate isomerase]
Synonyms

TPI
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wierenga RK, et al. Triosephosphate isomerase: a highly evolved biocatalyst. Cell Mol Life Sci. 2010;67(23):3961-3982. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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