331830-20-7
331830-20-7
Chemical Structure
1,4-DPCA
- CAS No.: 331830-20-7
- Formula:C13H8N2O3
- Molecular Weight:240.21
IUPAC Name: 4-oxo-4,4a-dihydro-1,10-phenanthroline-3-carboxylic acid
InChIKey: YZRSIMPDMZRLJK-UHFFFAOYSA-N
SMILES: O=C(C1=CN=C2C3=NC=CC=C3C=CC2C1=O)O
Biological Activity: 1,4-DPCA, a potent prolyl-4-hydroxylase inhibitor, is a collagen hydroxylation inhibitor in human foreskin fibroblasts with an IC50 of 2.4 µM. 1,4-DPCA inhibits prolyl-4-hydroxylases α isoforms stabilizes HIF-1α protein. 1,4-DPCA also inhibits factor inhibiting HIF (FIH) with an IC50 of 60 μM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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1,4-DPCA | 99.78% | 1,4-DPCA, a potent prolyl-4-hydroxylase inhibitor, is a collagen hydroxylation inhibitor in human foreskin fibroblasts with an IC50 of 2.4 µM. 1,4-DPCA inhibits prolyl-4-hydroxylases α isoforms stabilizes HIF-1α protein. 1,4-DPCA also inhibits factor inhibiting HIF (FIH) with an IC50 of 60 μM. | ||||||||||||||||||||
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References
- [1]. Yong Zhang, et al. Drug-induced regeneration in adult mice. Sci Transl Med. 2015 Jun 3;7(290):290ra92. [Content Brief]
- [2]. Ryan J Love, et al. Transient inhibition of connective tissue infiltration and collagen deposition into porous poly(lactic-co-glycolic acid) discs. J Biomed Mater Res A. 2013 Dec;101(12):3599-606. [Content Brief]
Keywords
