3431-16-1
Chemical Structure
VEC6
Synonym(s): NSC 11435
- CAS No.: 3431-16-1
- Formula:C14H20N4
- Molecular Weight:244.34
IUPAC Name: (E)-9-methyl-3-(phenyldiazenyl)-3,9-diazabicyclo[3.3.1]nonane
InChIKey: HSCMOVCUZWPGDL-FOCLMDBBSA-N
SMILES: CN(C(CCC1)C2)C1CN2/N=N/C3=CC=CC=C3
Biological Activity: VEC6 (NSC 11435) is an inhibitor of VEZF1–DNA interaction and has the activity to recapitulate RhoB loss in ischemic retinopathy. VEC6 reduces pathological angiogenesis and promotes lymphangiogenesis. VEC6 plays a unique role in angiogenesis and lymphangiogenesis by regulating the expression of different sets of genes in endothelial cells. VEC6 has an inhibitory effect on VEZF1-mediated transcriptional activity, thereby affecting the proliferation and sprouting of endothelial cells[1].
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VEC6 | VEC6 (NSC 11435) is an inhibitor of VEZF1–DNA interaction and has the activity to recapitulate RhoB loss in ischemic retinopathy. VEC6 reduces pathological angiogenesis and promotes lymphangiogenesis. VEC6 plays a unique role in angiogenesis and lymphangiogenesis by regulating the expression of different sets of genes in endothelial cells. VEC6 has an inhibitory effect on VEZF1-mediated transcriptional activity, thereby affecting the proliferation and sprouting of endothelial cells. | |||||||||||||||||||||
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Keywords
