353787-70-9
353787-70-9
Chemical Structure
Prostaglandin F2α ethanolamide
Synonym(s): Prostamide F2α
- CAS No.: 353787-70-9
- Formula:C22H39NO5
- Molecular Weight:397.55
IUPAC Name: (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)cyclopentyl)-N-(2-hydroxyethyl)hept-5-enamide
InChIKey: XCVCLIRZZCGEMU-WLOFLUCMSA-N
SMILES: CCCCC[C@H](O)/C=C/[C@@H]1[C@H]([C@H](C[C@H]1O)O)C/C=C\CCCC(NCCO)=O
Biological Activity: Prostaglandin F2α ethanolamide (Prostamide F2α) is an ethanolamide-like G protein-coupled receptor. Prostaglandin F2α is also a luteinizing hormone in sheep and may be a nociceptive mediator in the spinal cord[1][2][3].
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Prostaglandin F2α ethanolamide | 98.2% | Prostaglandin F2α ethanolamide (Prostamide F2α) is an ethanolamide-like G protein-coupled receptor. Prostaglandin F2α is also a luteinizing hormone in sheep and may be a nociceptive mediator in the spinal cord. | ||||||||||||||||||||
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References
- [1]. Richie-Jannetta R, et al. Structural determinants for calcium mobilization by prostaglandin E2 and prostaglandin F2alpha glyceryl esters in RAW 264.7 cells and H1819 cells. Prostaglandins Other Lipid Mediat. 2010 Jun;92(1-4):19-24. [Content Brief]
- [2]. Woodward DF, et al. Recent progress in prostaglandin F2α ethanolamide (prostamide F2α) research and therapeutics. Pharmacol Rev. 2013 Jul 26;65(4):1135-47. [Content Brief]
- [3]. McCracken J A, et al. Prostaglandin F2α identified as a luteolytic hormone in sheep[J]. Nature New Biology, 1972, 238(83): 129-134.
Keywords
