355017-63-9
Chemical Structure
(+)-Allohydroxycitric acid calcium hydrate
- CAS No.: 355017-63-9
- Formula:C6H10CaO9
- Molecular Weight:286.26
SMILES: OC([C@@H](O)[C@](C(O)=O)(O)CC(O)=O)=O.[3/2].[Ca].O
Biological Activity: (+)-Allohydroxycitric acid calcium hydrate is a weak acetyl-CoA carboxylase (ACC) activator with a Km of 20 mM. (+)-Allohydroxycitric acid calcium hydrate can replace citrate to activate ACC in vitro, but does not produce an in vivo agonistic effect in vivo. (+)-Allohydroxycitric acid calcium hydrate cannot alter the rates of hepatic fatty acid and cholesterol synthesis in rats, and has no lipid-regulating effect. (+)-Allohydroxycitric acid calcium hydrate can be used for metabolism-related research[1][2].
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(+)-Allohydroxycitric acid calcium hydrate | (+)-Allohydroxycitric acid calcium hydrate is a weak acetyl-CoA carboxylase (ACC) activator with a Km of 20 mM. (+)-Allohydroxycitric acid calcium hydrate can replace citrate to activate ACC in vitro, but does not produce an in vivo agonistic effect in vivo. (+)-Allohydroxycitric acid calcium hydrate cannot alter the rates of hepatic fatty acid and cholesterol synthesis in rats, and has no lipid-regulating effect. (+)-Allohydroxycitric acid calcium hydrate can be used for metabolism-related research. | |||||||||||||||||||||
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References
- [1]. Triscari J, et al. Comparative effects of (--)-hydroxycitrate and (+)-allo-hydroxycitrate on acetyl CoA carboxylase and fatty acid and cholesterol synthesis in vivo. Lipids. 1977 Apr;12(4):357-63.
- [2]. Glusker J P. The structure and absolute configuration of the calcium salt of garcinia acid, the lactone of (-)-hydroxycitric acid. Acta Cryst. 1971;B27:1284-1293.
