355022-97-8
355022-97-8
Chemical Structure
Anxiolytic/nonsedative agent-1
- CAS No.: 355022-97-8
- Formula:C18H15N3O4
- Molecular Weight:337.33
IUPAC Name: (R)-2-(5-nitro-1H-indol-3-yl)-2-oxo-N-(1-phenylethyl)acetamide
InChIKey: VCKKJKQZHHPPDR-LLVKDONJSA-N
SMILES: O=C(N[C@@H](C1=CC=CC=C1)C)C(C2=CNC3=C2C=C([N+]([O-])=O)C=C3)=O
Biological Activity: Anxiolytic/nonsedative agent-1 (compound 2b) is a potent and selective GABAA agonist. Anxiolytic/nonsedative agent-1 shows appreciable affinity for the BzR in bovine brain membranes with Kis of 14, 121, 239 nM for α1β2γ2, α2β2γ2, α5β3γ2, respectively. Anxiolytic/nonsedative agent-1 shows α2 selective efficacy in vitro and anxioselective effects in vivo[1].
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Anxiolytic/nonsedative agent-1 | Anxiolytic/nonsedative agent-1 (compound 2b) is a potent and selective GABAA agonist. Anxiolytic/nonsedative agent-1 shows appreciable affinity for the BzR in bovine brain membranes with Kis of 14, 121, 239 nM for α1β2γ2, α2β2γ2, α5β3γ2, respectively. Anxiolytic/nonsedative agent-1 shows α2 selective efficacy in vitro and anxioselective effects in vivo. | |||||||||||||||||||||
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