3617-45-6
3617-45-6
Chemical Structure
L-Phenylalanyl-L-glutamic acid
Synonym(s): H-Phe-Glu-OH
- CAS No.: 3617-45-6
- Formula:C14H18N2O5
- Molecular Weight:294.30
IUPAC Name: L-phenylalanyl-L-glutamic acid
InChIKey: JXWLMUIXUXLIJR-QWRGUYRKSA-N
SMILES: O=C(CC[C@H](NC([C@@H](N)CC1=CC=CC=C1)=O)C(O)=O)O
Biological Activity: L-Phenylalanyl-L-glutamic acid (H-Phe-Glu-OH) is a dipeptide present in the exudates of alfalfa seedlings, which exhibits high affinity for PEPT2. L-Phenylalanyl-L-glutamic acid can serve as the peptide scaffold of a tyrosyl-tRNA synthetase inhibitor against Staphylococcus aureus[1][2][3].
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L-Phenylalanyl-L-glutamic acid | L-Phenylalanyl-L-glutamic acid (H-Phe-Glu-OH) is a dipeptide present in the exudates of alfalfa seedlings, which exhibits high affinity for PEPT2. L-Phenylalanyl-L-glutamic acid can serve as the peptide scaffold of a tyrosyl-tRNA synthetase inhibitor against Staphylococcus aureus. | |||||||||||||||||||||
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References
- [1]. Abouzeid S, et al. Antibacterial and Antibiofilm Effects of Allelopathic Compounds Identified in Medicago sativa L. Seedling Exudate against Escherichia coli. Molecules. 2023 Mar 14;28(6):2645.
- [2]. Farshadfar C, et al. Novel potential inhibitor discovery against tyrosyl-tRNA synthetase from Staphylococcus aureus by virtual screening, molecular dynamics, MMPBSA and QMMM simulations. Mol Simul. 2020 Mar 31;46(7):507-520.
- [3]. Biegel A, et al. Structural requirements for the substrates of the H+/peptide cotransporter PEPT2 determined by three-dimensional quantitative structure-activity relationship analysis. J Med Chem. 2006 Jul 13;49(14):4286-96. [Content Brief]
