366477-44-3
366477-44-3
Chemical Structure
Haplophytin-A
- CAS No.: 366477-44-3
- Formula:C15H15NO3
- Molecular Weight:257.28
InChIKey: SMAYXCAPAZDLBX-UHFFFAOYSA-N
SMILES: O=C1NC2=C(C(OC)=CC=C2)C3=C1C=CC(C)(C)O3
Biological Activity: Haplophytin-A is a quinoline alkaloid. Haplophytin-A is a potent apoptosis inducer that exerts robust anti-leukemic activity by activating the caspase-8-dependent apoptotic pathway. Haplophytin-A can be used for the research of promyelocytic leukemia[1][2].
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Haplophytin-A | Haplophytin-A is a quinoline alkaloid. Haplophytin-A is a potent apoptosis inducer that exerts robust anti-leukemic activity by activating the caspase-8-dependent apoptotic pathway. Haplophytin-A can be used for the research of promyelocytic leukemia. | |||||||||||||||||||||
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References
- [1]. Won KJ, et al. Haplophytin-A induces caspase-8-mediated apoptosis via the formation of death-inducing signaling complex in human promyelocytic leukemia HL-60 cells. Chem Biol Interact. 2010;188(3):505-511. [Content Brief]
- [2]. Ali MS, et al. Haplophytin-A and B: the alkaloidal constituents of Haplophyllum acutifolium. Phytochemistry. 2001;57(8):1277-1280. [Content Brief]
