387816-81-1
Chemical Structure
YM218 free base
- CAS No.: 387816-81-1
- Formula:C35H38F2N4O4
- Molecular Weight:616.70
IUPAC Name: (Z)-N-(4-(5-(2-([1,4'-bipiperidin]-1'-yl)-2-oxoethylidene)-4,4-difluoro-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-2-methylfuran-3-carboxamide
InChIKey: VDUUABBYYOPFAW-WMMMYUQOSA-N
SMILES: O=C(NC1=CC=C(C=C1)C(N2CCC(F)(/C(C3=CC=CC=C32)=C\C(N4CCC(CC4)N5CCCCC5)=O)F)=O)C6=C(OC=C6)C
Biological Activity: YM218 free base is an orally active non-peptide vasopressin (AVP) receptor antagonist. YM218 free base has a high affinity for rat liver V1A receptors with a Ki value of 0.50 nM; it has a lower affinity for rat pituitary V1B, kidney V2, and uterine oxytocin receptors with Ki values of 1510 nM, 72.2 nM, and 150 nM, respectively. YM218 free base can be used in the study of diabetes and kidney disease[1].
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YM218 free base | YM218 free base is an orally active non-peptide vasopressin (AVP) receptor antagonist. YM218 free base has a high affinity for rat liver V1A receptors with a Ki value of 0.50 nM; it has a lower affinity for rat pituitary V1B, kidney V2, and uterine oxytocin receptors with Ki values of 1510 nM, 72.2 nM, and 150 nM, respectively. YM218 free base can be used in the study of diabetes and kidney disease. | |||||||||||||||||||||
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Keywords
