39080-67-6
Chemical Structure
Difludiazepam
Synonym(s): Ro 07-4065
- CAS No.: 39080-67-6
- Formula:C16H11ClF2N2O
- Molecular Weight:320.72
IUPAC Name: 7-chloro-5-(2,6-difluorophenyl)-1-methyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
InChIKey: DUNFPASORLTEGN-UHFFFAOYSA-N
SMILES: ClC1=CC(C(C2=C(C=CC=C2F)F)=NCC3=O)=C(N3C)C=C1
Biological Activity: Difludiazepam (Ro 07-4065), a benzodiazepine derivative, is a GABAA receptor ligand with an IC50 of 4.1 nM. Difludiazepam binds to an allosteric site on the GABAA receptor to potentiate the receptor's response to GABA, reducing neuron excitability. Difludiazepam contains halogenated groups at the ortho position of its phenyl ring[1][2].
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Difludiazepam | 98.02% | Difludiazepam (Ro 07-4065), a benzodiazepine derivative, is a GABAA receptor ligand with an IC50 of 4.1 nM. Difludiazepam binds to an allosteric site on the GABAA receptor to potentiate the receptor's response to GABA, reducing neuron excitability. Difludiazepam contains halogenated groups at the ortho position of its phenyl ring. | ||||||||||||||||||||
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- [1]. Manchester KR, et al. The blood-to-plasma ratio and predicted GABAA-binding affinity of designer benzodiazepines. Forensic Toxicol. 2022 Jul;40(2):349-356. [Content Brief]
- [2]. So SS, et al. Genetic neural networks for quantitative structure-activity relationships: improvements and application of benzodiazepine affinity for benzodiazepine/GABAA receptors. J Med Chem. 1996 Dec 20;39(26):5246-56. [Content Brief]
Keywords
