393129-91-4
393129-91-4
Chemical Structure
5-HT2B antagonist-1
- CAS No.: 393129-91-4
- Formula:C11H14BrN5
- Molecular Weight:296.17
IUPAC Name: N2-(4-bromophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine
InChIKey: NZEZISMBIMCMOR-UHFFFAOYSA-N
SMILES: BrC1=CC=C(NC2=NC(N)=NC(C)(C)N2)C=C1
Biological Activity: 5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease[1][2].
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5-HT2B antagonist-1 | 99.90% | 5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease. | ||||||||||||||||||||
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References
- [1]. Xiang Ma, et al. Synthesis and in vitro evaluation of 2,4-diamino-1,3,5-triazine derivatives as neuronal voltage-gated sodium channel blockers. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5644 [Content Brief]
- [2]. Yu Zhou, et al. Structure-Based Discovery of Novel and Selective 5-Hydroxytryptamine 2B Receptor Antagonists for the Treatment of Irritable Bowel Syndrome. J Med Chem. 2016 Jan 28;59(2):707-20. [Content Brief]
