4176-97-0
Chemical Structure
14-Deoxyandrographolide
- CAS No.: 4176-97-0
- Formula:C20H30O4
- Molecular Weight:334.45
IUPAC Name: 3-(2-((1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethyl)furan-2(5H)-one
InChIKey: GVRNTWSGBWPJGS-YSDSKTICSA-N
SMILES: O=C1OCC=C1CC[C@@H]2C(CC[C@]3([H])[C@](C)(CO)[C@H](O)CC[C@@]23C)=C
Biological Activity: 14-Deoxyandrographolide is a diterpene with calcium channel blocking activity and acts as a uterine smooth muscle relaxant. 14-Deoxyandrographolide stimulates the release of nitric oxide (NO) in endothelial cells. 14-Deoxyandrographolide gradually desensitizes liver cells to TNF-α mediated apoptosis by inducing the release of TNFRSF1A[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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14-Deoxyandrographolide | 99.94% | 14-Deoxyandrographolide is a diterpene with calcium channel blocking activity and acts as a uterine smooth muscle relaxant. 14-Deoxyandrographolide stimulates the release of nitric oxide (NO) in endothelial cells. 14-Deoxyandrographolide gradually desensitizes liver cells to TNF-α mediated apoptosis by inducing the release of TNFRSF1A. | ||||||||||||||||||||
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14-Deoxyandrographolide (Standard) | ≥98% | 14-Deoxyandrographolide (Standard) is the analytical standard of 14-Deoxyandrographolide. 14-Deoxyandrographolide is a diterpene with calcium channel blocking activity and acts as a uterine smooth muscle relaxant. 14-Deoxyandrographolide stimulates the release of nitric oxide (NO) in endothelial cells. 14-Deoxyandrographolide gradually desensitizes liver cells to TNF-α mediated apoptosis by inducing the release of TNFRSF1A. | ||||||||||||||||||||
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Similarity Score 0.85
HY-N9388Andrograpanin -
Similarity Score 0.82
HY-N0857Deoxyandrographolide -
Similarity Score 0.82
HY-N3054Pinusolidic acid -
Similarity Score 0.80
HY-N149014-Deoxy-11,12-didehydroandrographolide -
Similarity Score 0.79
HY-N149114-Deoxy-11-hydroxyandrographolide -
Similarity Score 0.79
HY-N149214-Deoxy-12-hydroxyandrographolide -
Similarity Score 0.79
HY-N20643(1R,4aS,5R,6R,8aS)-14-Deoxy-12-hydroxyandrographolide -
Similarity Score 0.78
HY-N148814-Deoxy-17-hydroxyandrographolide -
Similarity Score 0.75
HY-N9144ent-3β,18-Dihydroxylabda-8(17),13E-dien-15-oic acid -
Explore the MedChemAI to find more analogs
References
- [1]. Burgos RA, et al. Effect of 14-deoxyandrographolide on calcium-mediated rat uterine smooth muscle contractility. Phytother Res. 2003;17(9):1011-1015. [Content Brief]
- [2]. Roy DN, et al. 14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway. Br J Pharmacol. 2010 Aug;160(7):1823-43. [Content Brief]
- [3]. C Y Zhang, et al. Effects of 14-deoxyandrographolide and 14-deoxy-11,12-didehydroandrographolide on nitric oxide production in cultured human endothelial cells. Phytother Res. 1999 Mar;13(2):157-9. [Content Brief]
