423148-78-1
423148-78-1
Chemical Structure
PYZD-4409
- CAS No.: 423148-78-1
- Formula:C14H7ClFN3O5
- Molecular Weight:351.67
IUPAC Name: (Z)-1-(3-chloro-4-fluorophenyl)-4-((5-nitrofuran-2-yl)methylene)pyrazolidine-3,5-dione
InChIKey: MSYMKEYWUWVZQY-TWGQIWQCSA-N
SMILES: FC1=CC=C(N2C(/C(C(N2)=O)=C\C3=CC=C([N+]([O-])=O)O3)=O)C=C1Cl
Biological Activity: PYZD-4409 is a specific inhibitor of the ubiquitin-activating enzyme UBA1 with an IC50 of 20 μM (cell-free enzymatic assay). PYZD-4409 induces cell death in malignant cells and preferentially inhibits the clonogenic growth of primary acute myeloid leukemia cells[1].
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PYZD-4409 | 98.0% | PYZD-4409 is a specific inhibitor of the ubiquitin-activating enzyme UBA1 with an IC50 of 20 μM (cell-free enzymatic assay). PYZD-4409 induces cell death in malignant cells and preferentially inhibits the clonogenic growth of primary acute myeloid leukemia cells. | ||||||||||||||||||||
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References
Keywords
