446306-43-0
Chemical Structure
MEISi-1
- No. CAS: 446306-43-0
- Formula:C24H24N2O3
- Molecular Weight:388.46
IUPAC Name: 4-(2-(benzylamino)-2-oxoethoxy)-N-(2,3-dimethylphenyl)benzamide
InChIKey: MNJQVNZAPZMEDA-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(C)=C1C)C2=CC=C(OCC(NCC3=CC=CC=C3)=O)C=C2
Biological Activity: MEISi-1 is a small-molecule inhibitor targeting the homeodomain of the MEIS1 protein. MEISi-1 significantly inhibits the activity of luciferase reporter genes containing MEIS binding sites (TGACAG), and induces the self-renewal of a key type of mouse and human hematopoietic stem cells (HSC) both in vitro and in vivo. MEISi-1 promotes cardiomyocyte proliferation and cytokinesis, reduces cardiac fibroblast proliferation, and upregulates the expression of cardiomyocyte-specific genes. MEISi-1 can be used in research on hematological diseases, cardiac regeneration and cancer[1][2].
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MEISi-1 | 98.16% | MEISi-1 is a small-molecule inhibitor targeting the homeodomain of the MEIS1 protein. MEISi-1 significantly inhibits the activity of luciferase reporter genes containing MEIS binding sites (TGACAG), and induces the self-renewal of a key type of mouse and human hematopoietic stem cells (HSC) both in vitro and in vivo. MEISi-1 promotes cardiomyocyte proliferation and cytokinesis, reduces cardiac fibroblast proliferation, and upregulates the expression of cardiomyocyte-specific genes. MEISi-1 can be used in research on hematological diseases, cardiac regeneration and cancer. | ||||||||||||||||||||
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- [1]. Mammadova A, et al. Mechanistic insights into cardiac regeneration and protection through MEIS inhibition. Turkish journal of biology = Turk biyoloji dergisi. 2024;48(6):414-431. [Content Brief]
- [2]. Turan RD, et al. Development of Small Molecule MEIS Inhibitors that modulate HSC activity. Scientific reports. 2020 May 14;10(1):7994. [Content Brief]
Keywords
