503468-03-9
503468-03-9
Chemical Structure
NU-7163
- CAS. Nr.: 503468-03-9
- Formula:C18H17NO3
- Molecular Weight:295.33
IUPAC Name: 2-(2-methylmorpholino)-4H-benzo[h]chromen-4-one
InChIKey: RFWCIJWQGHFULK-UHFFFAOYSA-N
SMILES: O=C1C=C(N2CCOC(C2)C)OC3=C1C=CC4=C3C=CC=C4
Biological Activity: NU-7163 is an ATP-competitive DNA-PK inhibitor (IC50=0.19 μM; Ki=24 nM). NU-7163 enhances the cytotoxicity of ionizing radiation against the HeLa human tumor cell line in vitro[1].
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NU-7163 | NU-7163 is an ATP-competitive DNA-PK inhibitor (IC50=0.19 μM; Ki=24 nM). NU-7163 enhances the cytotoxicity of ionizing radiation against the HeLa human tumor cell line in vitro. | |||||||||||||||||||||
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References
- [1]. Griffin R J, et al. Selective benzopyranone and pyrimido [2, 1-a] isoquinolin-4-one inhibitors of dna-dependent protein kinase: synthesis, structure− activity studies, and radiosensitization of a human tumor cell line in vitro[J]. Journal of medicinal chemistry, 2005, 48(2): 569-585. [Content Brief]
Keywords
