511-96-6
511-96-6
Chemical Structure
Gitogenin
- CAS No.: 511-96-6
- Formula:C27H44O4
- Molecular Weight:432.64
IUPAC Name: (2aS,4R,5R,5'R,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bR)-5',6a,8a,9-tetramethyldocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4,5-diol
InChIKey: FWCXELAAYFYCSR-RYKNUXCGSA-N
SMILES: C[C@@H]1[C@@]2(CC[C@@H](C)CO2)O[C@]3([H])[C@@]1([H])[C@@]4([C@@]([C@@]5([H])[C@]([C@@]6([C@@](C[C@@H](O)[C@H](O)C6)([H])CC5)C)([H])CC4)([H])C3)C
Biological Activity: Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC50 values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Gitogenin | 99.93% | Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC50 values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms. | ||||||||||||||||||||
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Gitogenin (Standard) | ≥98% | Gitogenin (Standard) is the analytical standard of Gitogenin. This product is intended for research and analytical applications. Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC50 values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms. | ||||||||||||||||||||
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epi-Smilagenin | epi-Smilagenin is a 5β-spirostan-3α-ol and steroidal sapogenin. epi-Smilagenin can be found in the rumen content of sheep intoxicated by Brachiaria decumbens. | |||||||||||||||||||||
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Smilagenin (Standard) | ≥98% | Smilagenin (Standard) is the analytical standard of Smilagenin. This product is intended for research and analytical applications. Smilagenin (SMI) is a small-molecule steroidal sapogenin from Anemarrhena asphodeloides and Pelargonium hortorum widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases. Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density. Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD. | ||||||||||||||||||||
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Jurubidine | Jurubidine is a novel and potent cyclised aglycone. | |||||||||||||||||||||
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Ruizgenin | Ruizgenin is a new steroidal saponin diol extracted from Agave lecheguilla. | |||||||||||||||||||||
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Sarsasapogenin | 99.93% | Sarsasapogenin is a sapogenin from the Chinese medical herb Anemarrhena asphodeloides Bunge, with antidiabetic, anti-oxidative, anticancer and anti-inflamatory activities. | ||||||||||||||||||||
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Spirostan-3-ol | Spirostan-3-ol is a useful tool to keep bees away from areas recently treated with toxic insecticides. | |||||||||||||||||||||
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Chlorogenin | 99.95% | Chlorogenin is a natural product that can be isolated from the flowers of Agave americana. | ||||||||||||||||||||
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Markogenin | Markogenin is a steroid component from Yucca shidgera plants. | |||||||||||||||||||||
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Tigogenin | 98.0% | Tigogenin is a steroidal sapogenins. Tigogenin can inhibit adipocytic differentiation and induce osteoblastic differentiation in mouse bone marrow stromal cells. Tigogenin can inhibit cells proliferation and induce apoptosis. Tigogenin can be used for the researches of cancer, inflammation, immunology, metabolic and cardiovascular disease, such as mammary gland carcinoma, rheumatoid arthritis, osteoporosis and atherosclerosis. | ||||||||||||||||||||
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Neochlorogenin | Neochlorogenin is a spirostan-type steroidal saponin aglycone that can be naturally extracted from the dried leaves of Solanum torvum Sw. (Indian nightshade). | |||||||||||||||||||||
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References
- [1]. Xu M, et al. Drug interaction study of natural steroids from herbs specifically toward human UDP-glucuronosyltransferase (UGT) 1A4 and their quantitative structure activity relationship (QSAR) analysis for prediction. Pharmacol Res. 2016 Aug;110:139-150. [Content Brief]
- [2]. Xu M, et al. Drug interaction study of natural steroids from herbs specifically toward human UDP-glucuronosyltransferase (UGT) 1A4 and their quantitative structure activity relationship (QSAR) analysis for prediction. Pharmacol Res. 2016 Aug;110:139-150.
