518303-27-0
518303-27-0
Chemical Structure
Mcl1-IN-15
- CAS No.: 518303-27-0
- Formula:C22H23NO5S2
- Molecular Weight:445.55
IUPAC Name: 2-((4-((4-(tert-butyl)phenyl)sulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid
InChIKey: OPOQSWDNJPCXKP-UHFFFAOYSA-N
SMILES: O=C(O)CSC1=CC(NS(=O)(C2=CC=C(C(C)(C)C)C=C2)=O)=C3C=CC=CC3=C1O
Biological Activity: Mcl1-IN-15 (Compound 7) is the inhibitor for myeloid cell leukemia 1 (Mcl-1) with an IC50 of 8.73 μM. Mcl1-IN-15 inhibits Mcl1-BH3 peptide interaction, activates the Bak/Bax-mediated apoptosis and exhibits antitumor activity[1].
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Mcl1-IN-15 | Mcl1-IN-15 (Compound 7) is the inhibitor for myeloid cell leukemia 1 (Mcl-1) with an IC50 of 8.73 μM. Mcl1-IN-15 inhibits Mcl1-BH3 peptide interaction, activates the Bak/Bax-mediated apoptosis and exhibits antitumor activity. | |||||||||||||||||||||
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References
Keywords
