527680-56-4
527680-56-4
Chemical Structure
PHA 568487 free base
- CAS No.: 527680-56-4
- Formula:C16H20N2O3
- Molecular Weight:288.34
IUPAC Name: (R)-N-(quinuclidin-3-yl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamide
InChIKey: LUVXHMJTVXZFPD-ZDUSSCGKSA-N
SMILES: O=C(C1=CC=C2C(OCCO2)=C1)N[C@@H]3C(CC4)CCN4C3
Biological Activity: PHA 568487 free base is a selective alpha 7 nicotinic acetylcholine receptor (α-7 nAchR) agonist. PHA 568487 free base reduces neuroinflammation[1][2][3].
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PHA 568487 free base | 99.29% | PHA 568487 free base is a selective alpha 7 nicotinic acetylcholine receptor (α-7 nAchR) agonist. PHA 568487 free base reduces neuroinflammation. | ||||||||||||||||||||
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References
- [1]. F Barclay Shilliday, et al. Multiple species metabolism of PHA-568487, a selective alpha 7 nicotinic acetylcholine receptor agonist. Drug Metab Lett. 2010 Aug;4(3):162-72. [Content Brief]
- [2]. Zhenying Han, et al. Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture. J Neurochem. 2014 Nov;131(4):498-508. [Content Brief]
- [3]. Lorena Colás, et al. In vivo imaging of Α7 nicotinic receptors as a novel method to monitor neuroinflammation after cerebral ischemia. Glia. 2018 Aug;66(8):1611-1624. [Content Brief]
Keywords
