54483-84-0
Chemical Structure
3α-Dihydrocadambine
- CAS No.: 54483-84-0
- Formula:C27H34N2O10
- Molecular Weight:546.57
IUPAC Name: methyl (4S,4aS,5S,14bS,15aS)-5-hydroxy-4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4,4a,5,6,8,9,14,14b,15,15a-decahydropyrano[4'',3'':4',5']azepino[1',2':1,2]pyrido[3,4-b]indole-1-carboxylate
InChIKey: HNZGKRAKJFZQAY-SBAWYOAKSA-N
SMILES: O[C@@H]1CN2[C@](C[C@@](C(C(OC)=O)=CO3)([H])[C@]1([H])[C@@H]3O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]([C@H]4O)CO)([H])C5=C(CC2)C6=CC=CC=C6N5
Biological Activity: 3α-Dihydrocadambine is a natural product isolated from the heartwoods of Anthocephalus cadamba.3α-Dihydrocadambine exhibits dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats[1][2].
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3α-Dihydrocadambine | 3α-Dihydrocadambine is a natural product isolated from the heartwoods of Anthocephalus cadamba.3α-Dihydrocadambine exhibits dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats. | |||||||||||||||||||||
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References
- [1]. Takayama H, et al. Gluco-indole alkaloids from Nauclea cadamba in Thailand and transformation of 3 alpha-dihydrocadambine into the indolopyridine alkaloid, 16-carbomethoxynaufoline. Chem Pharm Bull (Tokyo). 2003;51(2):232-233. [Content Brief]
- [2]. K Aisaka, et al. Hypotensive action of 3 alpha-dihydrocadambine, an indole alkaloid glycoside of Uncaria hooks. Planta Med. 1985 Oct;51(5):424-7. [Content Brief]
