549-68-8
Chemical Structure
Octaverine
- CAS No.: 549-68-8
- Formula:C23H27NO5
- Molecular Weight:397.46
IUPAC Name: 6,7-dimethoxy-1-(3,4,5-triethoxyphenyl)isoquinoline
InChIKey: NGIFHAUKQGDVSR-UHFFFAOYSA-N
SMILES: N=1C=CC=2C=C(OC)C(OC)=CC2C1C=3C=C(OCC)C(OCC)=C(OCC)C3
Biological Activity: Octaverine is a synthetic isoquinoline alkaloid with oral activity and adrenergic lytic activity. Octaverine antagonizes the pressor effect of adrenaline, elevates the toxicity threshold of adrenaline, and reduces blood pressure. Octaverine increases respiratory depth, respiratory frequency, ventilation rate, and coronary blood flow. Octaverine inhibits spontaneous uterine contractions, antagonizes induced intestinal spasms, alleviates histamine-induced bronchospasm, and exhibits favorable biosafety. Octaverine can be used in research related to intestinal spasms and bronchospasm[1][2].
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Octaverine | Octaverine is a synthetic isoquinoline alkaloid with oral activity and adrenergic lytic activity. Octaverine antagonizes the pressor effect of adrenaline, elevates the toxicity threshold of adrenaline, and reduces blood pressure. Octaverine increases respiratory depth, respiratory frequency, ventilation rate, and coronary blood flow. Octaverine inhibits spontaneous uterine contractions, antagonizes induced intestinal spasms, alleviates histamine-induced bronchospasm, and exhibits favorable biosafety. Octaverine can be used in research related to intestinal spasms and bronchospasm. | |||||||||||||||||||||
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- [1]. GOLDBERG AA, SHAPERO M. A comparative study of the action of octaverine perparine and papaverine on the circulatory and respiratory systems. J Pharm Pharmacol. 1954 Apr;6(4):236-45.
- [2]. GOLDBERG AA, SHAPERO M. A comparative study of the spasmolytic activities of octaverine, perparine and papaverine. J Pharm Pharmacol. 1954 Mar;6(3):171-7.
Keywords
