554429-88-8
Chemical Structure
Estrogen receptor modulator 14
- CAS No.: 554429-88-8
- Formula:C39H45NO7
- Molecular Weight:639.79
IUPAC Name: (R)-5-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-5,11-dihydrochromeno[4,3-c]chromene-2,8-diyl bis(2,2-dimethylpropanoate)
InChIKey: HFEFFYLNWHUHTO-PGUFJCEWSA-N
SMILES: O(C(C(C)(C)C)=O)C=1C=C2C(C3=C(C=4C(O[C@@H]3C5=CC=C(OCCN6CCCCC6)C=C5)=CC(OC(C(C)(C)C)=O)=CC4)CO2)=CC1
Biological Activity: Estrogen receptor modulator 14 is a chromene-derived prodrug of selective Estrogen Receptor modulator with oral activity. Estrogen receptor modulator 14 undergoes hydrolysis in vivo to produce the active metabolite 2d-(R), which acts on ERα and ERβ. Estrogen receptor modulator 14 acts on central thermoregulatory sites and possesses the ability to regulate estrogen signaling in multiple systemic tissues. Estrogen receptor modulator 14 maintains antiestrogenic activity in the uterus, and alters plasma cholesterol and bone metabolism. Estrogen receptor modulator 14 can be used for the research of estrogen receptor-related diseases[1].
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Estrogen receptor modulator 14 | Estrogen receptor modulator 14 is a chromene-derived prodrug of selective Estrogen Receptor modulator with oral activity. Estrogen receptor modulator 14 undergoes hydrolysis in vivo to produce the active metabolite 2d-(R), which acts on ERα and ERβ. Estrogen receptor modulator 14 acts on central thermoregulatory sites and possesses the ability to regulate estrogen signaling in multiple systemic tissues. Estrogen receptor modulator 14 maintains antiestrogenic activity in the uterus, and alters plasma cholesterol and bone metabolism. Estrogen receptor modulator 14 can be used for the research of estrogen receptor-related diseases. | |||||||||||||||||||||
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Keywords
