55511-14-3
Chemical Structure
Schisandronic acid
Synonym(s): Ganwuweizic acid
- CAS No.: 55511-14-3
- Formula:C30H46O3
- Molecular Weight:454.68
IUPAC Name: (R,Z)-2-methyl-6-((2aR,3R,5aS,5bS,7aR,11aR,12aS)-2a,5a,8,8-tetramethyl-9-oxotetradecahydro-1H,12H-cyclopenta[a]cyclopropa[e]phenanthren-3-yl)hept-2-enoic acid
InChIKey: MZPNVEOVZSHYMZ-RRKDZSPHSA-N
SMILES: C[C@H](CC/C=C(C)\C(O)=O)[C@H]1CC[C@@]2(C)[C@@H]3CC[C@H]4C(C(CC[C@@]45C[C@@]35CC[C@]12C)=O)(C)C
Biological Activity: Schisandronic acid is a triterpenoid antioxidant and anticancer agent extracted from Schisandra chinensis, which has potent cytotoxicity against human breast cancer cells, especially MCF-7. Schisandronic acid induces apoptosis and reduces cell viability in a time-dependent manner (MCF-7, IC50=8.06 μM). Schisandronic acid can upregulate active caspase-3 expression and cleave PARP, reduce the generation of reactive oxygen species and exhibit antioxidant effects[1].
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Schisandronic acid | Schisandronic acid is a triterpenoid antioxidant and anticancer agent extracted from Schisandra chinensis, which has potent cytotoxicity against human breast cancer cells, especially MCF-7. Schisandronic acid induces apoptosis and reduces cell viability in a time-dependent manner (MCF-7, IC50=8.06 μM). Schisandronic acid can upregulate active caspase-3 expression and cleave PARP, reduce the generation of reactive oxygen species and exhibit antioxidant effects. | |||||||||||||||||||||
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Keywords
