56105-81-8
56105-81-8
Chemical Structure
(R)-Ketoprofen
- CAS No.: 56105-81-8
- Formula:C16H14O3
- Molecular Weight:254.28
IUPAC Name: (R)-2-(3-benzoylphenyl)propanoic acid
InChIKey: DKYWVDODHFEZIM-LLVKDONJSA-N
SMILES: C[C@H](C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O
Biological Activity: (R)-Ketoprofen is an orally active nonsteroidal anti-inflammatory drug (NSAID) with analgesic properties. (R)-Ketoprofen does not significantly amplify the increase of inflammatory cytokines (such as tumor necrosis factor (TNF) and interleukin-1 (IL-1)) induced by LPS, but it can inhibit the anti-inflammatory activity of (S)-Ketoprofen[1][2].
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(R)-Ketoprofen | 95.0% | (R)-Ketoprofen is an orally active nonsteroidal anti-inflammatory drug (NSAID) with analgesic properties. (R)-Ketoprofen does not significantly amplify the increase of inflammatory cytokines (such as tumor necrosis factor (TNF) and interleukin-1 (IL-1)) induced by LPS, but it can inhibit the anti-inflammatory activity of (S)-Ketoprofen. | ||||||||||||||||||||
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References
- [1]. Estrada-Valenzuela D, et al. Lipase Assisted (S)-Ketoprofen Resolution from Commercially Available Racemic Mixture. Pharmaceuticals (Basel). 2021 Sep 29;14(10):996. [Content Brief]
- [2]. Ghezzi P, et al. Differential contribution of R and SIsomers in ketoprofen anti-inflammatory activity: role of cytokine modulation[J]. Journal of Pharmacology and Experimental Therapeutics, 1998, 287(3): 969-974. [Content Brief]
