567-72-6
Chemical Structure
Delta3,5-cholestadien-7-one
- CAS No.: 567-72-6
- Formula:C27H42O
- Molecular Weight:382.62
InChIKey: TTXJJFWWNDJDNR-CZRUWHASSA-N
SMILES: O=C1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCCC(C)C)(CC[C@]2([H])[C@@]4(C(C=CCC4)=C1)C)C
Biological Activity: Delta3,5-cholestadien-7-one is an oxysterol and a negative allosteric modulator of GABAA receptors. Delta3,5-cholestadien-7-one reduces GABA-induced currents in HEK cells expressing α1β1γ2 or α4β3γ2 subunit-containing GABAA receptors with IC50 values of 1.5 and 1 µM, respectively. Delta3,5-cholestadien-7-one reduces GABA-induced depolarization of peptidergic and non-peptidergic nociceptors, C-LTMRs, and cold thermosensors in isolated mouse dorsal root ganglion (DRG) neurons[1][2].
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Delta3,5-cholestadien-7-one | 95% | Delta3,5-cholestadien-7-one is an oxysterol and a negative allosteric modulator of GABAA receptors. Delta3,5-cholestadien-7-one reduces GABA-induced currents in HEK cells expressing α1β1γ2 or α4β3γ2 subunit-containing GABAA receptors with IC50 values of 1.5 and 1 µM, respectively. Delta3,5-cholestadien-7-one reduces GABA-induced depolarization of peptidergic and non-peptidergic nociceptors, C-LTMRs, and cold thermosensors in isolated mouse dorsal root ganglion (DRG) neurons. | ||||||||||||||||||||
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Cholesta-3,5-diene-7-one-d7 | Cholesta-3,5-diene-7-one-25,26,26,26,27,27,27-d7 is the deuterium labeled Cholesta-3,5-diene-7-one-25,26,26,26,27,27,27. | |||||||||||||||||||||
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