573678-04-3
573678-04-3
Chemical Structure
MK-2295
Synonym(s): NGD-8243
- CAS No.: 573678-04-3
- Formula:C21H12F6N4
- Molecular Weight:434.34
IUPAC Name: N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)quinazolin-4-amine
InChIKey: VTANGSDRFFLTSQ-UHFFFAOYSA-N
SMILES: C1=CC(=C(N=C1)C2=CC3=C(C=C2)C(=NC=N3)NC4=CC=C(C=C4)C(F)(F)F)C(F)(F)F
Biological Activity: MK-2295 (NGD-8243) is a TRPV1 antagonist. MK-2295 is an analgesic agent, and can be used for research of pain[1][2].
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MK-2295 | MK-2295 (NGD-8243) is a TRPV1 antagonist. MK-2295 is an analgesic agent, and can be used for research of pain. | |||||||||||||||||||||
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References
- [1]. Gunthorpe MJ, et al. Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway. Drug Discov Today. 2009 Jan;14(1-2):56-67. [Content Brief]
- [2]. Arthur Gomtsyan, et al. Chapter 8 - Clinical and Preclinical Experience with TRPV1 Antagonists as Potential Analgesic Agents. TRP Channels as Therapeutic Targets. From Basic Science to Clinical Use. 2015, Pages 129-144.
