57719-81-0
Chemical Structure
ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid
- CAS No.: 57719-81-0
- Formula:C20H28O4
- Molecular Weight:332.43
IUPAC Name: (4R,4aS,6aR,9S,11S,11aS,11bR)-11-hydroxy-4,11b-dimethyl-8-methylene-7-oxotetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylic acid
InChIKey: NSFLYGNWNATSHL-UKFLMKJWSA-N
SMILES: O=C1C([C@@]2([H])C[C@]13[C@]([C@@H](O)C2)([H])[C@]4([C@]([C@@](C)(CCC4)C(O)=O)([H])CC3)C)=C
Biological Activity: ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is an anti-melanin synthesis tyrosinase inhibitor, which can be isolated from Pteris fern. ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid regulates the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF). The 11α-OH, 15-oxo and 16-en moieties of ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid are key fragments that inhibit melanin synthesis. The 19-COOH moiety has been implicated in the inhibition of cytotoxicity associated with 11α-OH KA and related compounds[1].
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ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid | ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is an anti-melanin synthesis tyrosinase inhibitor, which can be isolated from Pteris fern. ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid regulates the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF). The 11α-OH, 15-oxo and 16-en moieties of ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid are key fragments that inhibit melanin synthesis. The 19-COOH moiety has been implicated in the inhibition of cytotoxicity associated with 11α-OH KA and related compounds. | |||||||||||||||||||||
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