579494-66-9
Chemical Structure
AZD 3043
Synonym(s): THRX 918661
- CAS No.: 579494-66-9
- Formula:C19H29NO5
- Molecular Weight:351.44
IUPAC Name: propyl 2-(4-(2-(diethylamino)-2-oxoethoxy)-3-ethoxyphenyl)acetate
InChIKey: QPUVKSKJCNGSGT-UHFFFAOYSA-N
SMILES: CCCOC(CC1=CC=C(OCC(N(CC)CC)=O)C(OCC)=C1)=O
Biological Activity: AZD 3043 (THRX 918661) is a positive allosteric modulator of GABA(A) receptors with sedative and hypnotic activity. AZD 3043 can enhance GABA(A) receptor-mediated chloride currents in vitro and produce hypnotic and electroencephalographic inhibitory effects in vivo. Due to its esterase-dependent metabolic pathway, it has a short duration of action and can be quickly cleared even after long-term infusion, which may have clinical application potential.
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AZD 3043 | AZD 3043 (THRX 918661) is a positive allosteric modulator of GABA(A) receptors with sedative and hypnotic activity. AZD 3043 can enhance GABA(A) receptor-mediated chloride currents in vitro and produce hypnotic and electroencephalographic inhibitory effects in vivo. Due to its esterase-dependent metabolic pathway, it has a short duration of action and can be quickly cleared even after long-term infusion, which may have clinical application potential. | |||||||||||||||||||||
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Keywords
