58688-54-3
58688-54-3
Chemical Structure
5,6-Dehydroarachidonic acid
- CAS No.: 58688-54-3
- Formula:C20H30O2
- Molecular Weight:302.45
IUPAC Name: (8Z,11Z,14Z)-icosa-8,11,14-trien-5-ynoic acid
InChIKey: GIOQWSLKUVKKAO-QNEBEIHSSA-N
SMILES: CCCCC/C=C\C/C=C\C/C=C\CC#CCCCC(O)=O
Biological Activity: 5,6-Dehydroarachidonic acid is a 5-lipoxygenase (Lipoxygenase) inhibitor that inhibits the biosynthesis of leukotrienes. However, 5,6-Dehydroarachidonic acid had no effect on vascular cell proliferation[1][2][3].
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5,6-Dehydroarachidonic acid | 5,6-Dehydroarachidonic acid is a 5-lipoxygenase (Lipoxygenase) inhibitor that inhibits the biosynthesis of leukotrienes. However, 5,6-Dehydroarachidonic acid had no effect on vascular cell proliferation. | |||||||||||||||||||||
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References
- [1]. Sok DE, et al. Inhibition of leukotriene biosynthesis by acetylenic analogs. Biochem Biophys Res Commun. 1982 Jul 16;107(1):101-8. [Content Brief]
- [2]. Dethlefsen SM, et al. Arachidonic acid metabolites in bFGF-, PDGF-, and serum-stimulated vascular cell growth. Exp Cell Res. 1994 Jun;212(2):262-73. [Content Brief]
- [3]. Corey E J, et al. Synthesis of three potential inhibitors of the biosynthesis of leukotrienes A–E[J]. Tetrahedron Letters, 1980, 21(44): 4243-4246.
Keywords
