59456-70-1
Chemical Structure
Nikkomycin Z
- CAS No.: 59456-70-1
- Formula:C20H25N5O10
- Molecular Weight:495.44
IUPAC Name: (S)-2-((2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanamido)-2-((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)acetic acid
InChIKey: WWJFFVUVFNBJTN-VHDFTHOZSA-N
SMILES: O[C@@H]1[C@H](O)[C@@H]([C@@H](C(O)=O)NC([C@@H](N)[C@@H]([C@H](O)C2=NC=C(O)C=C2)C)=O)O[C@H]1N3C(NC(C=C3)=O)=O
Biological Activity: Nikkomycin Z is a nucleoside peptide and an orally active antifungal agent. Nikkomycin Z inhibits chitin synthesis by acting as a competitive analogue of the chitin synthase substrate UDP-N-acetylglucosamine. Nikkomycin Z has antifungal activity[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Nikkomycin Z | 98.53% | Nikkomycin Z is a nucleoside peptide and an orally active antifungal agent. Nikkomycin Z inhibits chitin synthesis by acting as a competitive analogue of the chitin synthase substrate UDP-N-acetylglucosamine. Nikkomycin Z has antifungal activity. | ||||||||||||||||||||
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References
- [1]. R Kovács, et al. Synergistic Effect of Nikkomycin Z With Caspofungin and Micafungin Against Candida Albicans and Candida Parapsilosis Biofilms. Lett Appl Microbiol. 2019 Oct;69(4):271-278. [Content Brief]
- [2]. Goldberg J, et al. Comparison of nikkomycin Z with amphotericin B and itraconazole for treatment of histoplasmosis in a murine model. Antimicrobial Agents and Chemotherapy, 2000, 44(6): 1624-1629.
- [3]. Nix DE, et al. Pharmacokinetics of nikkomycin Z after single rising oral doses. Antimicrob Agents Chemother. 2009 Jun;53(6):2517-21. [Content Brief]
