60851-34-5
60851-34-5
Chemical Structure
2,3,4,6,7,8-Hexachlorodibenzofuran
Synonym(s): 2,3,4,6,7,8-HxCDF
- CAS No.: 60851-34-5
- Formula:C12H2Cl6O
- Molecular Weight:374.86
InChIKey: XTAHLACQOVXINQ-UHFFFAOYSA-N
SMILES: ClC1=C(Cl)C(Cl)=C(OC2=C(Cl)C(Cl)=C(Cl)C=C23)C3=C1
Biological Activity: 2,3,4,6,7,8-Hexachlorodibenzofuran (2,3,4,6,7,8-HxCDF) is a dioxin-like polychlorinated dibenzofuran (PCDF). 2,3,4,6,7,8-Hexachlorodibenzofuran induces expression of the genes encoding aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC50s = 0.687 and 0.575 nM, respectively)[1][2].
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2,3,4,6,7,8-Hexachlorodibenzofuran | 2,3,4,6,7,8-Hexachlorodibenzofuran (2,3,4,6,7,8-HxCDF) is a dioxin-like polychlorinated dibenzofuran (PCDF). 2,3,4,6,7,8-Hexachlorodibenzofuran induces expression of the genes encoding aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC50s = 0.687 and 0.575 nM, respectively). | |||||||||||||||||||||
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References
- [1]. Harnly M, et al. Polychlorinated Dibenzo-p-dioxin and Dibenzofuran Contamination at Metal Recovery Facilities, Open Burn Sites, and a Railroad Car Incineration Facility. Environ Sci Technol. 1995 Mar 1;29(3):677-84. [Content Brief]
- [2]. Bandiera S, et al. Polychlorinated dibenzofurans (PCDFs): effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity. Toxicology. 1984 Aug;32(2):131-44. [Content Brief]
