623578-11-0
623578-11-0
Chemical Structure
KU-0058684
- CAS No.: 623578-11-0
- Formula:C19H14FN3O3
- Molecular Weight:351.33
IUPAC Name: 1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)phenyl)pyrrolidine-2,5-dione
InChIKey: YQSZNYLPVBOGPO-UHFFFAOYSA-N
SMILES: O=C(N1C2=CC(CC3=NNC(C4=C3C=CC=C4)=O)=CC=C2F)CCC1=O
Biological Activity: KU-0058684 is a potent PARP inhibitor, with an IC50 of 3.2 nM for PARP-1. KU-0058684 significantly reduces DNA double strand break (DSB) repair[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KU-0058684 | 98.54% | KU-0058684 is a potent PARP inhibitor, with an IC50 of 3.2 nM for PARP-1. KU-0058684 significantly reduces DNA double strand break (DSB) repair. | ||||||||||||||||||||
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References
- [1]. Mitchell J, et al. Poly(ADP-Ribose) polymerase-1 and DNA-dependent protein kinase have equivalent roles in double strand break repair following ionizing radiation. Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1520-7. [Content Brief]
- [2]. McCabe N, et al. BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency. Cancer Biol Ther. 2005 Sep;4(9):934-6. [Content Brief]
