62574-06-5
Chemical Structure
Diacetylcercosporin
- CAS. Nr.: 62574-06-5
- Formula:C33H30O12
- Molecular Weight:618.58
IUPAC Name: (2S,2'S)-(5,12-dihydroxy-7,10-dimethoxy-6,11-dioxo-6,11-dihydroperyleno[1,12-def][1,3]dioxepine-8,9-diyl)bis(propane-1,2-diyl) diacetate
InChIKey: AAWYBWDUDOICBF-STQMWFEESA-N
SMILES: COC(C1=O)=C(C2=C(C3=C4C(O)=CC5=C3C6=C(C=C(C1=C26)O)OCO5)C(C[C@H](C)OC(C)=O)=C(C4=O)OC)C[C@H](C)OC(C)=O
Biological Activity: Diacetylcercosporin is a perylenequinone produced by Cercospora and Septoria that has diverse biological activities. Diacetylcercosporin inhibits the growth of P. falciparum strains that are sensitive and resistant to chloroquine (IC50s=2.75 and 1.94 μM for D6 and W2 clones, respectively) and L. donovani parasites (IC50=3.1 μM) in vitro. Diacetylcercosporin exhibits cytotoxicity against SK-MEL, KB, BT549, and SKOV3 human cancer cell lines (IC50s=4.8-8.7 μM). Diacetylcercosporin is also a phytotoxin that inhibits the growth of lettuce and bentgrass at a concentration of 1.62 mM.
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Diacetylcercosporin | Diacetylcercosporin is a perylenequinone produced by Cercospora and Septoria that has diverse biological activities. Diacetylcercosporin inhibits the growth of P. falciparum strains that are sensitive and resistant to chloroquine (IC50s=2.75 and 1.94 μM for D6 and W2 clones, respectively) and L. donovani parasites (IC50=3.1 μM) in vitro. Diacetylcercosporin exhibits cytotoxicity against SK-MEL, KB, BT549, and SKOV3 human cancer cell lines (IC50s=4.8-8.7 μM). Diacetylcercosporin is also a phytotoxin that inhibits the growth of lettuce and bentgrass at a concentration of 1.62 mM. | |||||||||||||||||||||
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