637328-69-9
Chemical Structure
Tanogitran
- CAS No.: 637328-69-9
- Formula:C25H31N7O3
- Molecular Weight:477.56
IUPAC Name: (R)-2-((2-(2-(((4-carbamimidoylphenyl)amino)methyl)-1-methyl-1H-benzo[d]imidazol-5-yl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)amino)acetic acid
InChIKey: MAOALPSHCIBFJZ-RUZDIDTESA-N
SMILES: O=C(N1CCCC1)[C@@](C)(C2=CC=C(N(C(CNC3=CC=C(C=C3)C(N)=N)=N4)C)C4=C2)NCC(O)=O
Biological Activity: Tanogitran is a dual inhibitor targeting Factor Xa and thrombin (thrombin), with Ki values of 26 and 2.7 nM, respectively. Tanogitran exhibits anticoagulant activity and can be used for research in thrombotic diseases[1][2].
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Tanogitran | Tanogitran is a dual inhibitor targeting Factor Xa and thrombin (thrombin), with Ki values of 26 and 2.7 nM, respectively. Tanogitran exhibits anticoagulant activity and can be used for research in thrombotic diseases. | |||||||||||||||||||||
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- [1]. Gómez-Outes A, et al. New parenteral anticoagulants in development. Ther Adv Cardiovasc Dis. 2011 Feb;5(1):33-59. [Content Brief]
- [2]. Remko M, et al. Theoretical Study of Molecular Structure and Physicochemical Properties of Novel Factor Xa Inhibitors and Dual Factor Xa and Factor IIa Inhibitors. Molecules. 2016 Feb 4;21(2):185. [Content Brief]
Keywords
