64088-62-6
Chemical Structure
(D-Tyr11)-Neurotensin
- CAS No.: 64088-62-6
- Formula:C78H121N21O20
- Molecular Weight:1672.92
InChIKey: PCJGZPGTCUMMOT-CJTVYESKSA-N
SMILES: OC(C=C1)=CC=C1C[C@H](C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CC(C)C)=O)=O)NC([C@H]2N(CCC2)C([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H]3N(CCC3)C([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@H](CCC(O)=O)NC([C@@H](NC([C@H](CC(C)C)NC([C@H]4NC(CC4)=O)=O)=O)CC5=CC=C(C=C5)O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: (D-Tyr11)-Neurotensin is an agonist of neurotensin receptor (Neurotensin Receptor) and an inhibitor of glutamatergic neurotransmission. Activation of NTR1 in the VTA by (D-Tyr11)-Neurotensin enhances glutamatergic inputs to non-dopaminergic neurons, mediating reward and dopamine efflux; meanwhile, activation of NTR2 reduces glutamatergic excitatory postsynaptic currents (EPSC) in dopaminergic neurons. (D-Tyr11)-Neurotensin can be used in studies related to schizophrenia[1][2][3][4].
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(D-Tyr11)-Neurotensin | (D-Tyr11)-Neurotensin is an agonist of neurotensin receptor (Neurotensin Receptor) and an inhibitor of glutamatergic neurotransmission. Activation of NTR1 in the VTA by (D-Tyr11)-Neurotensin enhances glutamatergic inputs to non-dopaminergic neurons, mediating reward and dopamine efflux; meanwhile, activation of NTR2 reduces glutamatergic excitatory postsynaptic currents (EPSC) in dopaminergic neurons. (D-Tyr11)-Neurotensin can be used in studies related to schizophrenia. | |||||||||||||||||||||
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References
- [1]. Rouibi K, et al. Ventral Midbrain NTS1 Receptors Mediate Conditioned Reward Induced by the Neurotensin Analog, D-Tyr[11]neurotensin. Frontiers in neuroscience. 2015;9:470.
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[2]. Steinberg, R., et al. "Neurochemical and behavioural effects of neurotensin vs [D-Tyr11] neurotensin on mesolimbic dopaminergic function." Neuropeptides 28.1 (1995): 43-50.
- [3]. Steinberg R, et al. Neurochemical and behavioural effects of neurotensin vs [D-Tyr11]neurotensin on mesolimbic dopaminergic function. Neuropeptides. 1995 Jan;28(1):43-50.
- [4]. Sotty F, et al. Comparative effects of neurotensin, neurotensin(8-13) and [D-Tyr(11)]neurotensin applied into the ventral tegmental area on extracellular dopamine in the rat prefrontal cortex and nucleus accumbens. Neuroscience. 2000;98(3):485-92. [Content Brief]
