64552-26-7
64552-26-7
Chemical Structure
MGL-IN-4
- CAS No.: 64552-26-7
- Formula:C9H8N2O2S
- Molecular Weight:208.24
InChIKey: DWVOOOVGVIEHIA-UHFFFAOYSA-N
SMILES: O=C(N)CN1SC2=CC=CC=C2C1=O
Biological Activity: MGL-IN-4 (compound 16) is a covalent monoacylglycerol lipase (MGL) inhibitor with an IC50 of 7.8 nM against hMGL. MGL-IN-4 covalently modifies a key cysteine residue of MGL through ring-opening release of an active sulfur atom, locking the lid domain in a closed conformation to allosterically inhibit its activity. MGL-IN-4 can be used in studies of neuroprotection and anti-inflammation[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
MGL-IN-4 | MGL-IN-4 (compound 16) is a covalent monoacylglycerol lipase (MGL) inhibitor with an IC50 of 7.8 nM against hMGL. MGL-IN-4 covalently modifies a key cysteine residue of MGL through ring-opening release of an active sulfur atom, locking the lid domain in a closed conformation to allosterically inhibit its activity. MGL-IN-4 can be used in studies of neuroprotection and anti-inflammation. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
