65840-95-1
Chemical Structure
Mycobactin-IN-1
- CAS No.: 65840-95-1
- Formula:C15H13ClN2O
- Molecular Weight:272.73
IUPAC Name: 2-(5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenol
InChIKey: BMOZIGVHPNPVGU-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C2NN=C(C2)C3=C(O)C=CC=C3)C=C1
Biological Activity: Mycobactin-IN-1, a pyrazoline analogue, is a mycobactin biosynthesis inhibitor against mycobacteria. Mycobactin-IN-1 binds to salicyl-AMP ligase (MbtA), a key enzyme in the mycobactin biosynthetic pathway. Mycobactin-IN-1 inhibits whole-cell drug efflux pumps in M. smegmatis. Mycobactin-IN-1 eradicates intracellularly surviving mycobacteria. Mycobactin-IN-1 shows an excellent in vivo pharmacokinetic profile. Mycobactin-IN-1 can be used for the research of tuberculosis[1].
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Mycobactin-IN-1 | 98.96% | Mycobactin-IN-1, a pyrazoline analogue, is a mycobactin biosynthesis inhibitor against mycobacteria. Mycobactin-IN-1 binds to salicyl-AMP ligase (MbtA), a key enzyme in the mycobactin biosynthetic pathway. Mycobactin-IN-1 inhibits whole-cell drug efflux pumps in M. smegmatis. Mycobactin-IN-1 eradicates intracellularly surviving mycobacteria. Mycobactin-IN-1 shows an excellent in vivo pharmacokinetic profile. Mycobactin-IN-1 can be used for the research of tuberculosis. | ||||||||||||||||||||
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Keywords
