Mycobactin-IN-1
Based on 1 Customer Validation
Mycobactin-IN-1, a pyrazoline analogue, is a mycobactin biosynthesis inhibitor against mycobacteria. Mycobactin-IN-1 binds to salicyl-AMP ligase (MbtA), a key enzyme in the mycobactin biosynthetic pathway. Mycobactin-IN-1 inhibits whole-cell drug efflux pumps in M. smegmatis. Mycobactin-IN-1 eradicates intracellularly surviving mycobacteria. Mycobactin-IN-1 shows an excellent in vivo pharmacokinetic profile. Mycobactin-IN-1 can be used for the research of tuberculosis.
For research use only. We do not sell to patients.
- Purity: 98.96%
- CAS No.: 65840-95-1
- Formula: C15H13ClN2O
- Molecular Weight:272.73
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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MCE Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Biological Activity
Mycobactin-IN-1 (compound 44) (0.125-256 μg/mL; 24 h, 72 h, 5 days, 8 days) strongly inhibits the growth of mycobacteria in both iron-deficient and iron-containing media. The MIC90 range of Mycobactin-IN-1 against Mycobacterium smegmatis, Mycobacterium tuberculosis, Mycobacterium aurum (ATCC 10437), and Mycobacterium bovis BCG is 4-128 μg/mL[1].
Mycobactin-IN-1 (4 μg/mL; 3 h) inhibits siderophore production in M. smegmatis with 54.70% efficacy[1].
Mycobactin-IN-1 (1 μg/mL) inhibits mycobacterial efflux pump activity[1].
Mycobactin-IN-1 (1-128 μg/mL; 48 h) has low cytotoxicity in normal cells[1].
Mycobactin-IN-1 (1-16 μg/mL; 72 h) effectively kills intracellular M. aurum in RAW\r\n264.7 macrophages with >90% inhibition at 16 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 murine macrophages, THP-1 human monocytes
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Concentration:1-128 μg/mL
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Incubation Time:48 h
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Result:Had GIC₉₀ values of 128 μg/mL (RAW 264.7) and 64 μg/mL (THP-1).
Chemical Information
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CAS No. 65840-95-1
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Appearance Solid
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Molecular Weight 272.73
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Formula C15H13ClN2O
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Color White to light yellow
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SMILES
ClC1=CC=C(C2NN=C(C2)C3=C(O)C=CC=C3)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (366.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6666 mL | 18.3331 mL | 36.6663 mL | 91.6657 mL |
| 5 mM | 0.7333 mL | 3.6666 mL | 7.3333 mL | 18.3331 mL | |
| 10 mM | 0.3667 mL | 1.8333 mL | 3.6666 mL | 9.1666 mL | |
| 15 mM | 0.2444 mL | 1.2222 mL | 2.4444 mL | 6.1110 mL | |
| 20 mM | 0.1833 mL | 0.9167 mL | 1.8333 mL | 4.5833 mL | |
| 25 mM | 0.1467 mL | 0.7333 mL | 1.4667 mL | 3.6666 mL | |
| 30 mM | 0.1222 mL | 0.6111 mL | 1.2222 mL | 3.0555 mL | |
| 40 mM | 0.0917 mL | 0.4583 mL | 0.9167 mL | 2.2916 mL | |
| 50 mM | 0.0733 mL | 0.3667 mL | 0.7333 mL | 1.8333 mL | |
| 60 mM | 0.0611 mL | 0.3056 mL | 0.6111 mL | 1.5278 mL | |
| 80 mM | 0.0458 mL | 0.2292 mL | 0.4583 mL | 1.1458 mL | |
| 100 mM | 0.0367 mL | 0.1833 mL | 0.3667 mL | 0.9167 mL |
Mycobactin-IN-1 Related Classifications
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