663941-66-0
Chemical Structure
8-CPT-cAMP-AM
Synonym(s): 8-(4-Chlorophenylthio)-cAMP-AM
- CAS No.: 663941-66-0
- Formula:C19H19ClN5O8PS
- Molecular Weight:543.87
IUPAC Name: (((4aR,6R,7R,7aS)-6-(6-amino-8-((4-chlorophenyl)thio)-9H-purin-9-yl)-7-hydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-yl)oxy)methyl acetate
InChIKey: XXDWNMLPFMCWLU-VWPRILESSA-N
SMILES: O[C@@H]1[C@H](OP2(OCOC(C)=O)=O)[C@@H](CO2)O[C@H]1N3C(SC4=CC=C(Cl)C=C4)=NC5=C3N=CN=C5N
Biological Activity: 8-CPT-cAMP-AM (8-(4-Chlorophenylthio)-cAMP-AM) is an Epac/PKA activator. 8-CPT-cAMP-AM potentiates glucose-dependent first- and second-phase insulin secretion, induces β-cell depolarization, modulates intracellular calcium via influx and ryanodine-sensitive store mobilization, and facilitates calcium-induced calcium release resistant to PKA inhibition. 8-CPT-cAMP-AM can be used for the research of cardiac hypertrophy, diabetic cardiomyopathy, and melanoma[1][2][3].
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8-CPT-cAMP-AM | 8-CPT-cAMP-AM (8-(4-Chlorophenylthio)-cAMP-AM) is an Epac/PKA activator. 8-CPT-cAMP-AM potentiates glucose-dependent first- and second-phase insulin secretion, induces β-cell depolarization, modulates intracellular calcium via influx and ryanodine-sensitive store mobilization, and facilitates calcium-induced calcium release resistant to PKA inhibition. 8-CPT-cAMP-AM can be used for the research of cardiac hypertrophy, diabetic cardiomyopathy, and melanoma. | |||||||||||||||||||||
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References
- [1]. Chepurny OG, et al. PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans. Am J Physiol Endocrinol Metab. 2010;298(3):E622-E633. [Content Brief]
- [2]. Sartoretto JL, et al. Regulation of VASP phosphorylation in cardiac myocytes: differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic heart. Am J Physiol Heart Circ Physiol. 2009;297(5):H1697-H1710. [Content Brief]
- [3]. Baljinnyam E, et al. Exchange protein directly activated by cyclic AMP increases melanoma cell migration by a Ca2+-dependent mechanism. Cancer Res. 2010;70(13):5607-5617. [Content Brief]
