678158-55-9
678158-55-9
Chemical Structure
CLZ-8
- CAS No.: 678158-55-9
- Formula:C22H23N3O2S
- Molecular Weight:393.50
IUPAC Name: (Z)-5-([1,1'-biphenyl]-4-ylmethylene)-2-(4-(2-hydroxyethyl)piperazin-1-yl)thiazol-4(5H)-one
InChIKey: IBEWMFVUBLAYJT-SILNSSARSA-N
SMILES: O=C1N=C(N2CCN(CCO)CC2)S/C1=C\C3=CC=C(C4=CC=CC=C4)C=C3
Biological Activity: CLZ-8 (Compound 8) is an orally active Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. CLZ-8 exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells[1].
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CLZ-8 | 99.14% | CLZ-8 (Compound 8) is an orally active Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. CLZ-8 exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells. | ||||||||||||||||||||
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References
Keywords
