67964-87-8
Chemical Structure
Stearoyl Serotonin
- CAS No.: 67964-87-8
- Formula:C28H46N2O2
- Molecular Weight:442.68
IUPAC Name: N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)stearamide
InChIKey: FKWHKBXVLNKTGT-UHFFFAOYSA-N
SMILES: O=C(CCCCCCCCCCCCCCCCC)NCCC1=CNC2=CC=C(C=C12)O
Biological Activity: Stearoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin. Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase (FAAH) and the transient receptor potential vanilloid-type 1 (TRPV1) channel, reducing both acute and chronic peripheral pain. The effects of replacing the arachidonoyl portion with the saturated 18-carbon stearoyl moiety have not been studied. However, replacement of arachidonate with saturated 11- or 12-carbon fatty acids produces compounds that potently inhibit capsaicin-induced TRPV1 channel activation (IC50=0.76 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 μM).
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Stearoyl Serotonin | 98.48% | Stearoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin. Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase (FAAH) and the transient receptor potential vanilloid-type 1 (TRPV1) channel, reducing both acute and chronic peripheral pain. The effects of replacing the arachidonoyl portion with the saturated 18-carbon stearoyl moiety have not been studied. However, replacement of arachidonate with saturated 11- or 12-carbon fatty acids produces compounds that potently inhibit capsaicin-induced TRPV1 channel activation (IC50=0.76 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 μM). | ||||||||||||||||||||
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Keywords
