722544-51-6
722544-51-6
Chemical Structure
Barasertib-HQPA
Synonym(s): AZD2811; INH-34; AZD1152-HQPA
- CAS No.: 722544-51-6
- Formula:C26H30FN7O3
- Molecular Weight:507.56
IUPAC Name: 2-(5-((7-(3-(ethyl(2-hydroxyethyl)amino)propoxy)quinazolin-4-yl)amino)-1H-pyrazol-3-yl)-N-(3-fluorophenyl)acetamide
InChIKey: QYZOGCMHVIGURT-UHFFFAOYSA-N
SMILES: O=C(CC1=NNC(NC2=C3C=CC(OCCCN(CCO)CC)=CC3=NC=N2)=C1)NC4=CC=CC(F)=C4
Biological Activity: Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor with an IC50 of 0.37 nM in a cell-free assay. Barasertib-HQPA (AZD2811) induces growth arrest and apoptosis in cancer cells[1].
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Barasertib-HQPA | 98.90% | Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor with an IC50 of 0.37 nM in a cell-free assay. Barasertib-HQPA (AZD2811) induces growth arrest and apoptosis in cancer cells. | ||||||||||||||||||||
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Barasertib-HQPA (Standard) | ≥98% | Barasertib-HQPA (Standard) is the analytical standard of Barasertib-HQPA (HY-10126). This product is intended for research and analytical applications. Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor with an IC50 of 0.37 nM in a cell-free assay. Barasertib-HQPA (AZD2811) induces growth arrest and apoptosis in cancer cells. | ||||||||||||||||||||
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References
- [1]. Yang, Jing., et al. AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. Blood. 2007 Sep 15;110(6):2034-40. [Content Brief]
