723746-47-2
Chemical Structure
LC28
- CAS No.: 723746-47-2
- Formula:C17H13BrClNO2
- Molecular Weight:378.65
IUPAC Name: (E)-4-bromo-2-(3-(4-chlorophenyl)acryloyl)-7-(methylamino)cyclohepta-2,4,6-trien-1-one
InChIKey: BUMNZRXLKXQECY-RUDMXATFSA-N
SMILES: O=C(C=CC1=CC=C(Cl)C=C1)C2=CC(Br)=CC=C(NC)C2=O
Biological Activity: LC28 is a STAT3 inhibitor with a human STAT3 Ki of 3.92 μM. LC28 targets the DNA-binding domain of STAT3, inhibits STAT3-DNA binding, and suppresses STAT3 signaling. LC28 induces apoptosis and suppresses survival of cisplatin-resistant ovarian cancer cells. LC28 can be used for the research of Cisplatin (HY-17394)-resistant ovarian cancer[1].
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LC28 | LC28 is a STAT3 inhibitor with a human STAT3 Ki of 3.92 μM. LC28 targets the DNA-binding domain of STAT3, inhibits STAT3-DNA binding, and suppresses STAT3 signaling. LC28 induces apoptosis and suppresses survival of cisplatin-resistant ovarian cancer cells. LC28 can be used for the research of Cisplatin (HY-17394)-resistant ovarian cancer. | |||||||||||||||||||||
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Keywords
