76298-89-0
Chemical Structure
Bromoacetylalprenololmenthane
Synonym(s): BrAAM
- CAS No.: 76298-89-0
- Formula:C24H37BrN2O3
- Molecular Weight:481.48
IUPAC Name: N-(2-(4-((3-(2-allylphenoxy)-2-hydroxypropyl)amino)-4-methylcyclohexyl)propan-2-yl)-2-bromoacetamide
InChIKey: UAXZWLFRPNDCMX-UHFFFAOYSA-N
SMILES: O=C(NC(C)(C)C1CCC(NCC(O)COC=2C=CC=CC2CC=C)(C)CC1)CBr
Biological Activity: Bromoacetylalprenololmenthane (BrAAM) is a competitive, slowly reversible β1-adrenoceptor antagonist with membrane-stabilizing effects. Bromoacetylalprenololmenthane causes parallel or non-parallel rightward shifts of the isoproterenol response curve and reversibly inhibits cardiac stimulatory responses. Bromoacetylalprenololmenthane can be used in studies such as determining the affinity constant of isoproterenol, occupancy-response relationships, and receptor reserve[1][2][3].
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Bromoacetylalprenololmenthane | Bromoacetylalprenololmenthane (BrAAM) is a competitive, slowly reversible β1-adrenoceptor antagonist with membrane-stabilizing effects. Bromoacetylalprenololmenthane causes parallel or non-parallel rightward shifts of the isoproterenol response curve and reversibly inhibits cardiac stimulatory responses. Bromoacetylalprenololmenthane can be used in studies such as determining the affinity constant of isoproterenol, occupancy-response relationships, and receptor reserve. | |||||||||||||||||||||
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References
- [1]. Surman AJ, et al. Alprenolol and bromoacetylalprenololmenthane are competitive slowly reversible antagonists at the beta 1-adrenoceptors of rat left atria. Journal of cardiovascular pharmacology. 1993 Jan;21(1):35-9. [Content Brief]
- [2]. Doggrell SA, et al. The effects of bromoacetylalprenololmenthane on the responses to isoprenaline of the left ventricle from normo-, prehyper- and hypertensive rats. Journal of autonomic pharmacology. 1997 Jun;17(3):183-90. [Content Brief]
- [3]. Box RJ, et al. Bromoacetylalprenololmenthane binding to beta-receptors modulates the rate of hormone-induced internalization but not desensitization in S49 cells. FEBS letters. 1987 Apr 20;214(2):323-6. [Content Brief]
